Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations | Zendy

Steve Bevan | Zendy; Matthew Traylor | Zendy; Poneh AdibSamii | Zendy; Rainer Malik | Zendy; Nicola Paul | Zendy; Caroline Jackson | Zendy; Martin Farrall | Zendy; Peter M. Rothwell | Zendy; Cathie Sudlow | Zendy; Martin Dichgans | Zendy; Hugh S. Markus | Zendy

Open Access

Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

Author(s) -

Steve Bevan,

Matthew Traylor,

Poneh AdibSamii,

Rainer Malik,

Nicola Paul,

Caroline Jackson,

Martin Farrall,

Peter M. Rothwell,

Cathie Sudlow,

Martin Dichgans,

Hugh S. Markus

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.665760

Subject(s) - medicine , heritability , stroke (engine) , candidate gene , ischemic stroke , genome wide association study , genetics , gene , single nucleotide polymorphism , genotype , ischemia , biology , mechanical engineering , engineering

The contribution of genetics to stroke risk, and whether this differs for different stroke subtypes, remainsuncertain. Genomewide complex trait analysis allows heritability to be assessed from genomewide association study (GWAS) data. Previous candidate gene studies have identified many associations with stoke but whether these are important requires replication in large independent data sets. GWAS data sets provide a powerful resource to perform replication studies.

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