Open AccessPerinatal Nicotine Exposure Increases Vulnerability of Hypoxic–Ischemic Brain Injury in Neonatal Rats
Author(s) -
Yong Li,
Daliao Xiao,
Chiranjib Dasgupta,
Fuxia Xiong,
Wenni Tong,
Shumei Yang,
Li Zhang
Publication year - 2012
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.112.664698
Subject(s) - medicine , nicotine , anesthesia , hypoxia (environmental) , cardiology , chemistry , organic chemistry , oxygen
Maternal cigarette smoking increases the risk of neonatal morbidity. We tested the hypothesis that perinatal nicotine exposure causes heightened brain vulnerability to hypoxic-ischemic (HI) injury in neonatal rats through aberrant expression patterns of angiotensin II type 1 (AT(1)R) and type 2 (AT(2)R) receptors in the developing brain.
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