Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats | Zendy

Xiang Fan | Zendy; MingMing Ning | Zendy; Eng H. Lo | Zendy; Xiaoying Wang | Zendy

Open Access

Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats

Author(s) -

Xiang Fan,

MingMing Ning,

Eng H. Lo,

Xiaoying Wang

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.663476

Subject(s) - medicine , tissue plasminogen activator , stroke (engine) , diabetes mellitus , insulin , thrombolysis , glycemic , plasminogen activator , infarction , t plasminogen activator , fibrinolytic agent , endocrinology , myocardial infarction , mechanical engineering , engineering

Therapeutic effects of early insulin glycemic control for poststroke hyperglycemia in combination with tissue-type plasminogen activator (tPA) thrombolytic therapy have not yet been studied but are of great clinical interest. In this study, we tested the effects of insulin plus tPA combination in a model of focal embolic stroke in Type I diabetic rats.

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