Mutant Erythropoietin Without Erythropoietic Activity Is Neuroprotective Against Ischemic Brain Injury | Zendy

Yu Gan | Zendy; Juan Xing | Zendy; Jing Zheng | Zendy; R. Anne Stetler | Zendy; Feng Zhang | Zendy; Yumin Luo | Zendy; Xunming Ji | Zendy; Yanqin Gao | Zendy; Guodong Cao | Zendy

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Mutant Erythropoietin Without Erythropoietic Activity Is Neuroprotective Against Ischemic Brain Injury

Author(s) -

Yu Gan,

Juan Xing,

Jing Zheng,

R. Anne Stetler,

Feng Zhang,

Yumin Luo,

Xunming Ji,

Yanqin Gao,

Guodong Cao

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.663120

Subject(s) - medicine , neuroprotection , erythropoietin , stroke (engine) , ischemic injury , ischemia , pharmacology , mechanical engineering , engineering

Erythropoietin (EPO) confers potent neuroprotection against ischemic injury. However, treatment for stroke requires high doses and multiple administrations of EPO, which may cause deleterious side effects due to its erythropoietic activity. This study identifies a novel nonerythropoietic mutant EPO and investigates its potential neuroprotective effects and underlying mechanism in an animal model of cerebral ischemia.

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