Intravenous Delivery of Adeno-Associated Viral Vector Serotype 9 Mediates Effective Gene Expression in Ischemic Stroke Lesion and Brain Angiogenic Foci | Zendy

Fanxia Shen | Zendy; Robert Kuo | Zendy; Marine Milon-Camus | Zendy; Zhenying Han | Zendy; Lidan Jiang | Zendy; William L. Young | Zendy; Hua Su | Zendy

Open Access

Intravenous Delivery of Adeno-Associated Viral Vector Serotype 9 Mediates Effective Gene Expression in Ischemic Stroke Lesion and Brain Angiogenic Foci

Author(s) -

Fanxia Shen,

Robert Kuo,

Marine Milon-Camus,

Zhenying Han,

Lidan Jiang,

William L. Young,

Hua Su

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.662965

Subject(s) - medicine , angiogenesis , adeno associated virus , genetic enhancement , gene delivery , pathology , lesion , viral vector , stroke (engine) , gene expression , immunology , vector (molecular biology) , cancer research , gene , biology , recombinant dna , mechanical engineering , biochemistry , engineering

Adeno-associated viral vector (AAV) is a powerful tool for delivering genes to treat brain diseases. Intravenous delivery of a self-complementary but not single-stranded AAV9 (ssAAV9) mediates robust gene expression in the adult brain. We tested if ssAAV9 effectively mediates gene expression in the ischemic stroke lesion and angiogenic foci.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research