White Matter Lesion Progression in LADIS
Author(s) -
Reinhold Schmidt,
Andrea Berghold,
Hanna Jokinen,
Alida A. Gouw,
Wiesje M. van der Flier,
Frederik Barkhof,
Philip Scheltens,
Katja Petrovic,
Sofia Madureira,
Ana Verdelho,
José M. Ferro,
Gunhild Waldemar,
Anders Wallin,
LarsOlof Wahlund,
Anna Poggesi,
Leonardo Pantoni,
Domenico Inzitari,
Franz Fazekas,
Timo Erkinjuntti
Publication year - 2012
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.112.662593
Subject(s) - medicine , hyperintensity , leukoaraiosis , dementia , cognition , cognitive decline , vascular dementia , magnetic resonance imaging , disease , psychiatry , radiology
White matter lesion (WML) progression has been advocated as a surrogate marker in intervention trials on cerebral small vessel disease. We assessed the rate of visually rated WML progression, studied correlations between lesion progression and cognition, and estimated sample sizes for clinical trials with pure WML progression vs combined WML progression-cognitive outcomes.
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