Open AccessRole of Protease-Activated Receptor-1 in Brain Injury After Experimental Global Cerebral Ischemia
Author(s) -
Jinhu Wang,
Hang Jin,
Ya Hua,
Richard F. Keep,
Guohua Xi
Publication year - 2012
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.112.661819
Subject(s) - medicine , ischemia , common carotid artery , knockout mouse , occlusion , thrombin , anesthesia , brain ischemia , receptor , cardiology , endocrinology , carotid arteries , platelet
Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays a role in brain injury after global cerebral ischemia.
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