Lipoprotein Phospholipase A2 and Cerebral Microbleeds in the Framingham Heart Study | Zendy

José R. Romero | Zendy; Sarah R. Preis | Zendy; Alexa S. Beiser | Zendy; Charles DeCarli | Zendy; Dong Young Lee | Zendy; Anand Viswanathan | Zendy; Emelia J. Benjamin | Zendy; João D. Fontes | Zendy; Rhoda Au | Zendy; Aleksandra Pikula | Zendy; Jimmy Wang | Zendy; Carlos S. Kase | Zendy; Philip A. Wolf | Zendy; Michael C. Irrizary | Zendy; Sudha Seshadri | Zendy

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Lipoprotein Phospholipase A2 and Cerebral Microbleeds in the Framingham Heart Study

Author(s) -

José R. Romero,

Sarah R. Preis,

Alexa S. Beiser,

Charles DeCarli,

Dong Young Lee,

Anand Viswanathan,

Emelia J. Benjamin,

João D. Fontes,

Rhoda Au,

Aleksandra Pikula,

Jimmy Wang,

Carlos S. Kase,

Philip A. Wolf,

Michael C. Irrizary,

Sudha Seshadri

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.656744

Subject(s) - medicine , framingham heart study , cardiology , cerebral atherosclerosis , atherosclerotic cardiovascular disease , framingham risk score , disease , vascular disease

Cerebral microbleeds (CMB) attributable to cerebral amyloid angiopathy generally occur in lobar regions, whereas those attributable to hypertensive vasculopathy are deep. Inflammation may be an underlying mechanism for CMB, with varying associations according to CMB location. Lipoprotein phospholipase-A2 (Lp-PLA2) is a circulating enzyme marker of vascular inflammation associated with risk of ischemic stroke and dementia. We hypothesized that higher Lp-PLA2 levels would be related to higher prevalence of CMB, with possible regional specificity.

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