Upregulation of Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E 2 Synthase-1 (mPGES-1) in Wall of Ruptured Human Cerebral Aneurysms | Zendy

David Hasan | Zendy; Tomoki Hashimoto | Zendy; David Kung | Zendy; R. Loch Macdonald | Zendy; H. Richard Winn | Zendy; Donald D. Heistad | Zendy

Open Access

Upregulation of Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E ₂ Synthase-1 (mPGES-1) in Wall of Ruptured Human Cerebral Aneurysms

Author(s) -

David Hasan,

Tomoki Hashimoto,

David Kung,

R. Loch Macdonald,

H. Richard Winn,

Donald D. Heistad

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.655829

Subject(s) - medicine , cyclooxygenase , aneurysm , prostaglandin , pathology , prostaglandin e , surgery , enzyme , biochemistry , chemistry

Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) catalyze isomerization of the cyclooxygenase product PGH2 into PGE2. Deletion of COX-2/mPGES-1 suppresses carotid artery atherogenesis and angiotensin II-induced aortic aneurysms formation, and attenuates neointimal hyperplasia after vascular injury in mice. The upregulation of COX-2/mPGES-1 in the wall of ruptured human cerebral aneurysms is not known.

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