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Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) catalyze isomerization of the cyclooxygenase product PGH2 into PGE2. Deletion of COX-2/mPGES-1 suppresses carotid artery atherogenesis and angiotensin II-induced aortic aneurysms formation, and attenuates neointimal hyperplasia after vascular injury in mice. The upregulation of COX-2/mPGES-1 in the wall of ruptured human cerebral aneurysms is not known.

Upregulation of Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E 2 Synthase-1 (mPGES-1) in Wall of Ruptured Human Cerebral Aneurysms

Upregulation of Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E ₂ Synthase-1 (mPGES-1) in Wall of Ruptured Human Cerebral Aneurysms