Image-Guided Method in the Rat for Inducing Cortical or Striatal Infarction and for Controlling Cerebral Blood Flow Under MRI | Zendy

Fabian Arnberg | Zendy; Johan Lundberg | Zendy; Michael Söderman | Zendy; Peter Damberg | Zendy; Staffan Holmin | Zendy

Open Access

Image-Guided Method in the Rat for Inducing Cortical or Striatal Infarction and for Controlling Cerebral Blood Flow Under MRI

Author(s) -

Fabian Arnberg,

Johan Lundberg,

Michael Söderman,

Peter Damberg,

Staffan Holmin

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.655126

Subject(s) - medicine , cerebral blood flow , cerebral infarction , infarction , stroke (engine) , blood flow , basal ganglia , magnetic resonance imaging , neuroscience , cardiology , pathology , radiology , central nervous system , ischemia , myocardial infarction , biology , mechanical engineering , engineering

Experimental models are essential for research on ischemic stroke, the second most common cause of death worldwide. The failure of clinical trials on neuroprotective treatment may be due in part to poor animal models. To push the translation of new therapies, we describe a new rat model that captures key elements of human brain ischemia. The model includes imaging and neurointerventional tools that represent the near future of clinical diagnosis and treatment of stroke.

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