Chronic Valproate Treatment Enhances Postischemic Angiogenesis and Promotes Functional Recovery in a Rat Model of Ischemic Stroke | Zendy

Zhifei Wang | Zendy; LiKai Tsai | Zendy; Jeeva Munasinghe | Zendy; Yan Leng | Zendy; Emily Fessler | Zendy; Fairouz Chibane | Zendy; Peter Leeds | Zendy; DeMaw Chuang | Zendy

Open Access

Chronic Valproate Treatment Enhances Postischemic Angiogenesis and Promotes Functional Recovery in a Rat Model of Ischemic Stroke

Author(s) -

Zhifei Wang,

LiKai Tsai,

Jeeva Munasinghe,

Yan Leng,

Emily Fessler,

Fairouz Chibane,

Peter Leeds,

DeMaw Chuang

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.652545

Subject(s) - medicine , angiogenesis , ischemia , vascular endothelial growth factor , cerebral blood flow , microvessel , hypoxia (environmental) , brain ischemia , pharmacology , anesthesia , endocrinology , chemistry , organic chemistry , oxygen , vegf receptors

Enhanced angiogenesis facilitates neurovascular remodeling processes and promotes brain functional recovery after stroke. Previous studies from our laboratory demonstrated that valproate (VPA), a histone deacetylase inhibitor, protects against experimental brain ischemia. The present study investigated whether VPA could enhance angiogenesis and promote long-term functional recovery after ischemic stroke.

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