Poor Prognosis in Warfarin-Associated Intracranial Hemorrhage Despite Anticoagulation Reversal | Zendy

Dar Dowlatshahi | Zendy; Kenneth Butcher | Zendy; Negar Asdaghi | Zendy; Susan Nahirniak | Zendy; Manya L. Bernbaum | Zendy; Antonio Giulivi | Zendy; Jason K. Wasserman | Zendy; Man-Chiu Poon | Zendy; Shelagh B. Coutts | Zendy

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Poor Prognosis in Warfarin-Associated Intracranial Hemorrhage Despite Anticoagulation Reversal

Author(s) -

Dar Dowlatshahi,

Kenneth Butcher,

Negar Asdaghi,

Susan Nahirniak,

Manya L. Bernbaum,

Antonio Giulivi,

Jason K. Wasserman,

Man-Chiu Poon,

Shelagh B. Coutts

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.652065

Subject(s) - medicine , interquartile range , glasgow coma scale , modified rankin scale , hematoma , intraparenchymal hemorrhage , warfarin , surgery , stroke (engine) , intracerebral hemorrhage , atrial fibrillation , ischemic stroke , subarachnoid hemorrhage , mechanical engineering , ischemia , engineering

Anticoagulant-associated intracranial hemorrhage (aaICH) presents with larger hematoma volumes, higher risk of hematoma expansion, and worse outcome than spontaneous intracranial hemorrhage. Prothrombin complex concentrates (PCCs) are indicated for urgent reversal of anticoagulation after aaICH. Given the lack of randomized controlled trial evidence of efficacy, and the potential for thrombotic complications, we aimed to determine outcomes in patients with aaICH treated with PCC.

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