Does the Application of X-Ray Contrast Agents Impair the Clinical Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients? | Zendy

Imanuel Dzialowski | Zendy; Volker Puetz | Zendy; Alastair M. Buchan | Zendy; Andrew M. Demchuk | Zendy; Michael D. Hill | Zendy

Open Access

Does the Application of X-Ray Contrast Agents Impair the Clinical Effect of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients?

Author(s) -

Imanuel Dzialowski,

Volker Puetz,

Alastair M. Buchan,

Andrew M. Demchuk,

Michael D. Hill

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.651737

Subject(s) - medicine , stroke (engine) , recombinant tissue plasminogen activator , plasminogen activator , intravenous contrast , recombinant dna , acute stroke , thrombolysis , ischemic stroke , tissue plasminogen activator , ischemia , cardiology , surgery , computed tomography , myocardial infarction , mechanical engineering , modified rankin scale , engineering , biochemistry , chemistry , gene

Experimental data suggest a negative interaction between x-ray contrast agents and fibrinolytic efficacy of recombinant tissue-type plasminogen activator (rtPA). We hypothesized that the application of a contrast agent before intravenous thrombolysis with rtPA reduces its clinical efficacy in acute ischemic stroke.

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