Reperfusion Rather than Ischemia Drives the Formation of Ubiquitin Aggregates After Middle Cerebral Artery Occlusion | Zendy

Karin Hochrainer | Zendy; Katherine Jackman | Zendy; Josef Anrather | Zendy; Costantino Iadecola | Zendy

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Reperfusion Rather than Ischemia Drives the Formation of Ubiquitin Aggregates After Middle Cerebral Artery Occlusion

Author(s) -

Karin Hochrainer,

Katherine Jackman,

Josef Anrather,

Costantino Iadecola

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.650416

Subject(s) - ischemia , ubiquitin , neocortex , medicine , middle cerebral artery , proteasome , striatum , infarction , brain ischemia , pathology , microbiology and biotechnology , biochemistry , biology , dopamine , myocardial infarction , psychiatry , gene

Cerebral ischemia leads to accumulation of ubiquitinated protein aggregates. However, the factors triggering ubiquitination and their impact on the outcome of cerebral ischemia remain poorly understood. Here we investigate the relationship between ubiquitin aggregation and duration of ischemia/reperfusion, infarct volume, and proteasomal activity in a mouse model of focal ischemia.

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