Pharmacological Induction of Heme Oxygenase-1 by a Triterpenoid Protects Neurons Against Ischemic Injury | Zendy

Feng Zhang | Zendy; Suping Wang | Zendy; Meijuan Zhang | Zendy; Zhongfang Weng | Zendy; Peiying Li | Zendy; Yu Gan | Zendy; Lili Zhang | Zendy; Guodong Cao | Zendy; Yanqin Gao | Zendy; Rehana K. Leak | Zendy; Michael B. Sporn | Zendy; Jun Chen | Zendy

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Pharmacological Induction of Heme Oxygenase-1 by a Triterpenoid Protects Neurons Against Ischemic Injury

Author(s) -

Feng Zhang,

Suping Wang,

Meijuan Zhang,

Zhongfang Weng,

Peiying Li,

Yu Gan,

Lili Zhang,

Guodong Cao,

Yanqin Gao,

Rehana K. Leak,

Michael B. Sporn,

Jun Chen

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.647420

Subject(s) - medicine , heme oxygenase , heme , triterpenoid , pharmacology , ischemic injury , oxygenase , anesthesia , traditional medicine , ischemia , biochemistry , enzyme , chemistry

Heme oxygenase-1 (HO-1) is an inducible Phase 2 enzyme that degrades toxic heme; its role in cerebral ischemia is not fully understood. We hypothesize that chemically induced HO-1 upregulation with the novel triterpenoid CDDO-Im (2-cyano-3,12 dioxooleana-1,9 dien-28-oyl imidazoline), a robust inducer of Phase 2 genes, protects neurons against ischemic injury.

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