Refinement of the Magnetic Resonance Diffusion-Perfusion Mismatch Concept for Thrombolytic Patient Selection | Zendy

Steven Warach | Zendy; Yasir AlRawi | Zendy; Anthony J. Furlan | Zendy; Jochen B. Fiebach | Zendy; Max Wintermark | Zendy; Annika Lindstén | Zendy; Jamal Smyej | Zendy; David B. Bharucha | Zendy; Salvador Pedraza | Zendy; Howard A. Rowley | Zendy

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Refinement of the Magnetic Resonance Diffusion-Perfusion Mismatch Concept for Thrombolytic Patient Selection

Author(s) -

Steven Warach,

Yasir AlRawi,

Anthony J. Furlan,

Jochen B. Fiebach,

Max Wintermark,

Annika Lindstén,

Jamal Smyej,

David B. Bharucha,

Salvador Pedraza,

Howard A. Rowley

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.642348

Subject(s) - medicine , penumbra , confidence interval , odds ratio , magnetic resonance imaging , placebo , clinical trial , sample size determination , lesion , perfusion , post hoc analysis , stroke (engine) , randomized controlled trial , nuclear medicine , cardiology , surgery , radiology , ischemia , pathology , mechanical engineering , engineering , statistics , alternative medicine , mathematics

The DIAS-2 study was the only large, randomized, intravenous, thrombolytic trial that selected patients based on the presence of ischemic penumbra. However, DIAS-2 did not confirm the positive findings of the smaller DEDAS and DIAS trials, which also used penumbral selection. Therefore, a reevaluation of the penumbra selection strategy is warranted.

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