Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic–Ischemic Stroke | Zendy

Jullet Han | Zendy; Julia Pollak | Zendy; Tao Yang | Zendy; Mohammad R. Siddiqui | Zendy; Kristian P. Doyle | Zendy; Kereshmeh TaravoshLahn | Zendy; Egle Cekanaviciute | Zendy; Alex Han | Zendy; Jeremy Goodman | Zendy; Britta E. Jones | Zendy; Deqiang Jing | Zendy; Stephen M. Massa | Zendy; Frank M. Longo | Zendy; Marion S. Buckwalter | Zendy

Open Access

Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic–Ischemic Stroke

Author(s) -

Jullet Han,

Julia Pollak,

Tao Yang,

Mohammad R. Siddiqui,

Kristian P. Doyle,

Kereshmeh TaravoshLahn,

Egle Cekanaviciute,

Alex Han,

Jeremy Goodman,

Britta E. Jones,

Deqiang Jing,

Stephen M. Massa,

Frank M. Longo,

Marion S. Buckwalter

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.641878

Subject(s) - neurogenesis , medicine , stroke (engine) , neuroprotection , neurotrophic factors , neuroplasticity , tropomyosin receptor kinase b , neurotrophin , neuroscience , stroke recovery , brain derived neurotrophic factor , angiogenesis , receptor , pharmacology , biology , physical therapy , rehabilitation , mechanical engineering , psychiatry , engineering

Stroke is the leading cause of long-term disability in the United States, yet no drugs are available that are proven to improve recovery. Brain-derived neurotrophic factor stimulates neurogenesis and plasticity, processes that are implicated in stroke recovery. It binds to both the tropomyosin-related kinase B and p75 neurotrophin receptors. However, brain-derived neurotrophic factor is not a feasible therapeutic agent, and no small molecule exists that can reproduce its binding to both receptors. We tested the hypothesis that a small molecule (LM22A-4) that selectively targets tropomyosin-related kinase B would promote neurogenesis and functional recovery after stroke.

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