Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction, and Matrix Metalloproteinase-9 Induction After Focal Cerebral Ischemia | Zendy

Ki Yong Lee | Zendy; OkNam Bae | Zendy; Kelsey Serfozo | Zendy; Siamk Hejabian | Zendy; Ahmad Moussa | Zendy; Mathew J. Reeves | Zendy; Wilson K. Rumbeiha | Zendy; Scott D. Fitzgerald | Zendy; Gary R Stein | Zendy; SeungHoon Baek | Zendy; John L. Goudreau | Zendy; Mounzer Kassab | Zendy; Arshad Majid | Zendy

Open Access

Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction, and Matrix Metalloproteinase-9 Induction After Focal Cerebral Ischemia

Author(s) -

Ki Yong Lee,

OkNam Bae,

Kelsey Serfozo,

Siamk Hejabian,

Ahmad Moussa,

Mathew J. Reeves,

Wilson K. Rumbeiha,

Scott D. Fitzgerald,

Gary R Stein,

SeungHoon Baek,

John L. Goudreau,

Mounzer Kassab,

Arshad Majid

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.639427

Subject(s) - medicine , ischemia , matrix metalloproteinase , cardiology , brain ischemia , matrix metalloproteinase 9 , cerebral ischaemia , anesthesia

Asiatic acid (AA) has been shown to attenuate cerebral infarction in a mouse model of focal ischemia and shows promise as a neuroprotective stroke therapy. To facilitate translation of these findings to clinical studies, we determined pharmacokinetics, a dose-response relationship, the therapeutic time window, and efficacy using multiple stroke models. We also explored potential mechanisms of action.

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