Systematic Review of Outcome After Ischemic Stroke Due to Anterior Circulation Occlusion Treated With Intravenous, Intra-Arterial, or Combined Intravenous+Intra-Arterial Thrombolysis | Zendy

Michael T. Mullen | Zendy; Jared M. Pisapia | Zendy; Shiv Tilwa | Zendy; Steven R. Messé | Zendy; Sherman C. Stein | Zendy

Open Access

Systematic Review of Outcome After Ischemic Stroke Due to Anterior Circulation Occlusion Treated With Intravenous, Intra-Arterial, or Combined Intravenous+Intra-Arterial Thrombolysis

Author(s) -

Michael T. Mullen,

Jared M. Pisapia,

Shiv Tilwa,

Steven R. Messé,

Sherman C. Stein

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.639211

Subject(s) - medicine , thrombolysis , modified rankin scale , intracerebral hemorrhage , stroke (engine) , randomized controlled trial , tissue plasminogen activator , observational study , fibrinolytic agent , anesthesia , t plasminogen activator , ischemia , surgery , cardiology , ischemic stroke , myocardial infarction , subarachnoid hemorrhage , mechanical engineering , engineering

The optimal approach to recanalization in acute ischemic stroke is unknown. We performed a literature review and meta-analysis comparing the relative efficacy of 6 reperfusion strategies: (1) 0.9 mg/kg intravenous tissue-type plasminogen activator; (2) intra-arterial chemical thrombolysis; (3) intra-arterial mechanical thrombolysis; (4) intra-arterial combined chemical/mechanical thrombolysis; (5) 0.6 mg/kg intravenous tissue-type plasminogen activator and intra-arterial thrombolysis; and (6) 0.9 mg/kg intravenous tissue-type plasminogen activator and intra-arterial thrombolysis.

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