Subacute Ischemic Stroke Is Associated With Focal 11 C PiB Positron Emission Tomography Retention But Not With Global Neocortical Aβ Deposition | Zendy

John Ly | Zendy; Christopher C. Rowe | Zendy; Victor L. Villemagne | Zendy; Jorge A. Zavala | Zendy; Henry Ma | Zendy; Ramesh Sahathevan | Zendy; Graeme O’Keefe | Zendy; Sylvia Gong | Zendy; Rico Gunawan | Zendy; Leonid Churilov | Zendy; Timothy Saunder | Zendy; Uwe Ackerman | Zendy; Henri TochonDanguy | Zendy; Geoffrey A. Donnan | Zendy

Open Access

Subacute Ischemic Stroke Is Associated With Focal ¹¹ C PiB Positron Emission Tomography Retention But Not With Global Neocortical Aβ Deposition

Author(s) -

John Ly,

Christopher C. Rowe,

Victor L. Villemagne,

Jorge A. Zavala,

Henry Ma,

Ramesh Sahathevan,

Graeme O’Keefe,

Sylvia Gong,

Rico Gunawan,

Leonid Churilov,

Timothy Saunder,

Uwe Ackerman,

Henri TochonDanguy,

Geoffrey A. Donnan

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.636266

Subject(s) - interquartile range , medicine , stroke (engine) , positron emission tomography , pittsburgh compound b , cerebral infarction , ischemia , cardiology , ischemic stroke , nuclear medicine , alzheimer's disease , disease , mechanical engineering , engineering

Conflicting evidence exists as to whether focal cerebral ischemia contributes to cerebral amyloid deposition. We aimed to look at Aβ deposits, detected by N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PiB) positron emission tomography, in patients with recent ischemic stroke. Specifically, we hypothesized that patients with recent ischemic stroke have higher local and neocortical PiB positron emission tomography retention and that this may be associated with major vascular risk factors.

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