Influence of the Arterial Input Function on Absolute and Relative Perfusion-Weighted Imaging Penumbral Flow Detection | Zendy

Olivier ZaroWeber | Zendy; Walter MoellerHartmann | Zendy; Wolf-Dieter Heiß | Zendy; Jan Sobesky | Zendy

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Influence of the Arterial Input Function on Absolute and Relative Perfusion-Weighted Imaging Penumbral Flow Detection

Author(s) -

Olivier ZaroWeber,

Walter MoellerHartmann,

Wolf-Dieter Heiß,

Jan Sobesky

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.635458

Subject(s) - medicine , cerebral blood flow , perfusion , positron emission tomography , nuclear medicine , perfusion scanning , emission computed tomography , receiver operating characteristic , blood flow , cerebral perfusion pressure , stroke (engine) , middle cerebral artery , radiology , cardiology , ischemia , physics , thermodynamics

Perfusion-weighted imaging maps are used to identify critical hypoperfusion in acute stroke. However, quantification of perfusion may depend on the choice of the arterial input function (AIF). Using quantitative positron emission tomography we evaluated the influence of the AIF location on maps of absolute and relative perfusion-weighted imaging to detect penumbral flow (PF; <20 mL/100 g/min on positron emission tomography(CBF)) in acute stroke.

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