A Rat Model of Studying Tissue-Type Plasminogen Activator Thrombolysis in Ischemic Stroke With Diabetes | Zendy

Xiang Fan | Zendy; Jianhua Qiu | Zendy; Zhanyang Yu | Zendy; Haibin Dai | Zendy; Aneesh B. Singhal | Zendy; Eng H. Lo | Zendy; Xiaoying Wang | Zendy

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A Rat Model of Studying Tissue-Type Plasminogen Activator Thrombolysis in Ischemic Stroke With Diabetes

Author(s) -

Xiang Fan,

Jianhua Qiu,

Zhanyang Yu,

Haibin Dai,

Aneesh B. Singhal,

Eng H. Lo,

Xiaoying Wang

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.635250

Subject(s) - medicine , thrombolysis , tissue plasminogen activator , plasminogen activator , diabetes mellitus , stroke (engine) , ischemic stroke , cardiology , ischemia , endocrinology , myocardial infarction , mechanical engineering , engineering

Poststroke hyperglycemia and diabetes mellitus are associated with lower thrombolytic efficacy and an increased risk of postischemic cerebral hemorrhage. We aimed to develop a rodent model of thrombolysis in diabetic stroke that mimics the clinical situation. Method- Male 6-week Type I diabetic rats (14 weeks old) were subjected to embolic focal stroke and treated with tissue-type plasminogen activator at 1.5 hours. Reperfusion and 24-hour neurological outcomes were measured and compared with nondiabetic control rats.

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