Netrin-1 Hyperexpression in Mouse Brain Promotes Angiogenesis and Long-Term Neurological Recovery After Transient Focal Ischemia | Zendy

Haiyan Lu | Zendy; Yongting Wang | Zendy; Xiaosong He | Zendy; Falei Yuan | Zendy; Xiaojie Lin | Zendy; Bohua Xie | Zendy; Guanghui Tang | Zendy; Jun Huang | Zendy; Yaohui Tang | Zendy; Kunlin Jin | Zendy; Shengdi Chen | Zendy; GuoYuan Yang | Zendy

Open Access

Netrin-1 Hyperexpression in Mouse Brain Promotes Angiogenesis and Long-Term Neurological Recovery After Transient Focal Ischemia

Author(s) -

Haiyan Lu,

Yongting Wang,

Xiaosong He,

Falei Yuan,

Xiaojie Lin,

Bohua Xie,

Guanghui Tang,

Jun Huang,

Yaohui Tang,

Kunlin Jin,

Shengdi Chen,

GuoYuan Yang

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.635235

Subject(s) - angiogenesis , medicine , neovascularization , pathology , western blot , in vivo , ischemia , microangiography , immunohistochemistry , biology , biochemistry , microbiology and biotechnology , gene

Netrin-1 (NT-1) stimulates endothelial cell proliferation and migration in vitro and promotes focal neovascularization in the adult brain in vivo. This in vivo study in mice investigated the effect of NT-1 hyperexpression on focal angiogenesis and long-term functional outcome after transient middle cerebral artery occlusion (tMCAO).

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