Letter by Lee Regarding Article, “Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Stroke” | Zendy

Regent Lee | Zendy

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Letter by Lee Regarding Article, “Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Stroke”

Author(s) -

Regent Lee

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.632869

Subject(s) - medicine , minocycline , stroke (engine) , mmp9 , mechanical engineering , biochemistry , chemistry , downregulation and upregulation , gene , microbiology and biotechnology , biology , engineering , antibiotics

To the Editor:Switzer et al investigated the effect of minocycline on plasma metalloproteinase-9 (MMP9) in acute ischemic stroke in the Minocycline to Improve Neurological Outcome in Stroke (MINOS) trial; they observed lower plasma MMP9 activity using zymography assay among tissue plasminogen activator-treated subjects.1Given the ready availability of enzyme immunoassays for quantitative measurements of MMP9, I am interested why the authors chose zymographic analysis of MMP9 activity for the study cohort instead. Throughout the manuscript, the authors …

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