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Are Myocardial Infarction–Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?
Author(s) -
Yu-Ching Cheng,
Christopher D. Anderson,
Silvia Bione,
Keith L. Keene,
Jane Maguire,
Michael A. Nalls,
Asif Rasheed,
Marion Zeginigg,
John Attia,
Ross Baker,
Simona Barlera,
Alessandro Biffi,
Ebony Bookman,
Thomas Brott,
Robert D. Brown,
Fang Chen,
WeiMin Chen,
Emilio Ciusani,
John W. Cole,
Lynelle Cortellini,
John Danesh,
Kimberly F. Doheny,
Luigi Ferrucci,
Maria Grazia Franzosi,
Philippe Frossard,
Karen L. Furie,
Jonathan Golledge,
Graeme J. Hankey,
Dena Hernandez,
Elizabeth Holliday,
FangChi Hsu,
Jim Jannes,
Ayeesha Kamran Kamal,
Muhammad Saleem Khan,
Steven J. Kittner,
Simon A. Koblar,
Martin Lewis,
Lisa F. Lincz,
Antonella Lisa,
Mar Matarín,
Pablo Moscato,
Josyf C. Mychaleckyj,
Eugenio Parati,
Silvia Parolo,
Elizabeth Pugh,
Natalia S. Rost,
Michael Schallert,
Helena Schmidt,
Rodney J. Scott,
Jonathan Sturm,
Sunaina Yadav,
Moazzam Zaidi,
Giorgio B. Boncoraglio,
Christopher Levi,
James F. Meschia,
Jonathan Rosand,
Michèle M. Sale,
Danish Saleheen,
Reinhold Schmidt,
Pankaj Sharma,
Bradford B. Worrall,
Braxton D. Mitchell
Publication year - 2012
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.111.632075
Subject(s) - medicine , ischemic stroke , single nucleotide polymorphism , stroke (engine) , myocardial infarction , cardiology , infarction , ischemia , genotype , gene , genetics , mechanical engineering , biology , engineering
Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated with myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently associated with MI or CAD through genome-wide association studies were associated with IS.

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