Late-Phase Contrast-Enhanced Ultrasound Reflects Biological Features of Instability in Human Carotid Atherosclerosis | Zendy

Joseph Shalhoub | Zendy; Claudia Monaco | Zendy; David R. Owen | Zendy; Thomas Gauthier | Zendy; Ankur Thapar | Zendy; Edward Leen | Zendy; Alun H. Davies | Zendy

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Late-Phase Contrast-Enhanced Ultrasound Reflects Biological Features of Instability in Human Carotid Atherosclerosis

Author(s) -

Joseph Shalhoub,

Claudia Monaco,

David R. Owen,

Thomas Gauthier,

Ankur Thapar,

Edward Leen,

Alun H. Davies

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.631200

Subject(s) - medicine , contrast enhanced ultrasound , carotid endarterectomy , microbubbles , cd68 , angiogenesis , cd31 , inflammation , atheroma , neovascularization , ultrasound , pathology , endarterectomy , stroke (engine) , radiology , fibrous cap , asymptomatic , immunohistochemistry , stenosis , mechanical engineering , engineering

Development of translational functional imaging modalities for atherosclerosis risk stratification is sought for stroke prediction. Our group has developed late-phase contrast-enhanced ultrasound (LP-CEUS) to quantify microbubble contrast retention within carotid atherosclerosis and shown it to separate asymptomatic plaques from those responsible for recent cerebrovascular events. We hypothesized that microbubbles are retained in areas of plaque inflammation, aiming to examine whether LP-CEUS signal reflects plaque biology.

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