Moderate Dietary Restriction Reduces p53-Mediated Neurovascular Damage and Microglia Activation After Hypoxic Ischemia in Neonatal Brain | Zendy

YiFang Tu | Zendy; PeiJung Lu | Zendy; Chao Huang | Zendy; Chien-Jung Ho | Zendy; Ya-Ping Chou | Zendy

Open Access

Moderate Dietary Restriction Reduces p53-Mediated Neurovascular Damage and Microglia Activation After Hypoxic Ischemia in Neonatal Brain

Author(s) -

YiFang Tu,

PeiJung Lu,

Chao Huang,

Chien-Jung Ho,

Ya-Ping Chou

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.629931

Subject(s) - microglia , apoptosis , medicine , brain damage , ischemia , tunel assay , programmed cell death , neuroprotection , inflammation , endocrinology , pathology , immunohistochemistry , biology , biochemistry

Neurovascular damage, including neuronal apoptosis and blood-brain barrier (BBB) damage, and microglia activation account for the hypoxic-ischemia (HI) susceptibility in neonatal brain. The p53 upregulation is involved in apoptosis, endothelial cell damage, and microglia activation. We hypothesized that underweight induced by dietary restriction (DR) protects against HI in rat pups by attenuating p53-mediated neurovascular damage.

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