Neuroprotection by Interleukin-6 Is Mediated by Signal Transducer and Activator of Transcription 3 and Antioxidative Signaling in Ischemic Stroke | Zendy

Joo Eun Jung | Zendy; Gab Seok Kim | Zendy; Pak H. Chan | Zendy

Open Access

Neuroprotection by Interleukin-6 Is Mediated by Signal Transducer and Activator of Transcription 3 and Antioxidative Signaling in Ischemic Stroke

Author(s) -

Joo Eun Jung,

Gab Seok Kim,

Pak H. Chan

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.626648

Subject(s) - medicine , neuroprotection , stat protein , signal transduction , stroke (engine) , activator (genetics) , neuroscience , ischemic stroke , transducer , pharmacology , immunology , ischemia , microbiology and biotechnology , stat3 , receptor , electrical engineering , biology , mechanical engineering , engineering

Interleukin-6 (IL-6) has been shown to have a neuroprotective effect in brain ischemic injury. However, its molecular mechanisms are still poorly understood. In this study, we investigated the neuroprotective role of the IL-6 receptor (IL-6R) by IL-6 in the reactive oxygen species defense system after transient focal cerebral ischemia (tFCI).

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