Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran | Zendy

Wei Zhou | Zendy; Sönke Schwarting | Zendy; Sergio Illanes | Zendy; Arthur Liesz | Zendy; Moritz Middelhoff | Zendy; Markus Zorn | Zendy; Martin Bendszus | Zendy; Sabine Heiland | Zendy; Joanne van Ryn | Zendy; Roland Veltkamp | Zendy

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Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran

Author(s) -

Wei Zhou,

Sönke Schwarting,

Sergio Illanes,

Arthur Liesz,

Moritz Middelhoff,

Markus Zorn,

Martin Bendszus,

Sabine Heiland,

Joanne van Ryn,

Roland Veltkamp

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.624650

Subject(s) - dabigatran , medicine , intracerebral hemorrhage , fresh frozen plasma , prothrombin complex concentrate , hematoma , anesthesia , recombinant factor viia , direct thrombin inhibitor , clotting time , coagulation , stroke (engine) , bleeding time , pharmacology , warfarin , surgery , atrial fibrillation , platelet , mechanical engineering , platelet aggregation , subarachnoid hemorrhage , engineering

Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with dabigatran, and to test the efficacy of different hemostatic factors in preventing hematoma growth.

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