Potential of Early [ 18 F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model | Zendy

Maureen Walberer | Zendy; Heiko Backes | Zendy; Maria Adele Rueger | Zendy; Bernd Neumaier | Zendy; Heike Endepols | Zendy; Mathias Hoehn | Zendy; Gereon R. Fink | Zendy; Michael Schroeter | Zendy; Rudolf Graf | Zendy

Open Access

Potential of Early [ ¹⁸ F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model

Author(s) -

Maureen Walberer,

Heiko Backes,

Maria Adele Rueger,

Bernd Neumaier,

Heike Endepols,

Mathias Hoehn,

Gereon R. Fink,

Michael Schroeter,

Rudolf Graf

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.624551

Subject(s) - medicine , positron emission tomography , cerebral blood flow , middle cerebral artery , nuclear medicine , blood flow , ischemia , stroke (engine) , occlusion , perfusion , mechanical engineering , engineering

Experimental stroke models are essential to study in vivo pathophysiological processes of focal cerebral ischemia. In this study, an embolic stroke model in rats was applied (1) to characterize early development of regional cerebral blood flow and metabolism with positron emission tomography (PET) using [(15)O]H(2)O and [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG); and (2) to identify potential parameters for predicting tissue fate.

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