Minocycline-Induced Attenuation of Iron Overload and Brain Injury After Experimental Intracerebral Hemorrhage | Zendy

Fan Zhao | Zendy; Ya Hua | Zendy; Yangdong He | Zendy; Richard F. Keep | Zendy; Guohua Xi | Zendy

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Minocycline-Induced Attenuation of Iron Overload and Brain Injury After Experimental Intracerebral Hemorrhage

Author(s) -

Fan Zhao,

Ya Hua,

Yangdong He,

Richard F. Keep,

Guohua Xi

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.623926

Subject(s) - minocycline , medicine , microglia , intracerebral hemorrhage , deferoxamine , pharmacology , edema , brain damage , anesthesia , inflammation , biochemistry , chemistry , subarachnoid hemorrhage , antibiotics

Brain iron overload plays a detrimental role in brain injury after intracerebral hemorrhage (ICH). A recent study found that minocycline acts as an iron chelator and reduces iron-induced neuronal death in vitro. The present study investigated if minocycline reduces iron overload after ICH and iron-induced brain injury in vivo.

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