Proliferating Reactive Astrocytes Are Regulated by Notch-1 in the Peri-Infarct Area After Stroke | Zendy

Issei S. Shimada | Zendy; Alyssa Borders | Zendy; Alexander Aronshtam | Zendy; Jeffrey L. Spees | Zendy

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Proliferating Reactive Astrocytes Are Regulated by Notch-1 in the Peri-Infarct Area After Stroke

Author(s) -

Issei S. Shimada,

Alyssa Borders,

Alexander Aronshtam,

Jeffrey L. Spees

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.623280

Subject(s) - glial fibrillary acidic protein , astrocyte , notch signaling pathway , medicine , pathology , conditional gene knockout , microbiology and biotechnology , signal transduction , biology , cancer research , immunology , central nervous system , immunohistochemistry , biochemistry , phenotype , gene

The formation of reactive astrocytes is common after central nervous system injuries such as stroke. However, the signaling pathway(s) that control astrocyte formation and functions are poorly defined. We assess the effects of Notch 1 signaling in peri-infarct-reactive astrocytes after stroke.

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