Open AccessAncrod and Fibrin Formation
Author(s) -
Shuo Liu,
Victor J. Marder,
David E. Levy,
ShurJen Wang,
Fan Yang,
Annlia PaganiniHill,
Mark Fisher
Publication year - 2011
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.111.622753
Subject(s) - fibrin , fibrinolysis , medicine , fibrinogen , plasminogen activator , tissue plasminogen activator , endothelial stem cell , stroke (engine) , endocrinology , in vitro , immunology , biochemistry , biology , mechanical engineering , engineering
Ancrod, derived from Malayan pit viper venom, has been tested as ischemic stroke treatment in clinical trials with inconsistent results. We studied the actions of ancrod on fibrinolysis pathways in patient plasma samples and endothelial cell culture systems.
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