Longitudinal Magnetic Resonance Imaging of Sildenafil Treatment of Embolic Stroke in Aged Rats
Author(s) -
Guangliang Ding,
Quan Jiang,
Lian Li,
Li Zhang,
Zhenggang Zhang,
Mei Lü,
Qingjiang Li,
Steven Gu,
James R. Ewing,
Michael Chopp
Publication year - 2011
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.111.622092
Subject(s) - medicine , sildenafil , stroke (engine) , ventricle , atrophy , magnetic resonance imaging , ischemia , cardiology , saline , anesthesia , radiology , mechanical engineering , engineering
Sildenafil provides restorative therapeutic benefits in the treatment of experimental stroke. The majority of experimental studies on treatment of stroke have been performed in young animals; however, stroke is primarily a disease of the aged. Thus, using MRI, we evaluated the effects of sildenafil treatment of embolic stroke in aged animals.
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