Reduced Efficacy of Circulating Costimulatory Cells After Focal Cerebral Ischemia | Zendy

Andreas Hug | Zendy; Arthur Liesz | Zendy; Bettina Muerle | Zendy; Wei Zhou | Zendy; Julia Ehrenheim | Zendy; Alexander Lorenz | Zendy; Alexander H. Dalpke | Zendy; Roland Veltkamp | Zendy

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Reduced Efficacy of Circulating Costimulatory Cells After Focal Cerebral Ischemia

Author(s) -

Andreas Hug,

Arthur Liesz,

Bettina Muerle,

Wei Zhou,

Julia Ehrenheim,

Alexander Lorenz,

Alexander H. Dalpke,

Roland Veltkamp

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.620948

Subject(s) - il 2 receptor , medicine , immune system , immunology , t cell , cd28 , t lymphocyte , ex vivo , interleukin 21 , cytotoxic t cell , microbiology and biotechnology , in vivo , biology , in vitro , biochemistry

Cerebral ischemia is ensued by a cellular immune depression syndrome. The postischemic functional capacity of T lymphocytes is controversial, and interactions between leukocyte subsets are largely unknown. Understanding the immunologic interplay between antigen-presenting cells and lymphocytes as well as between distinct lymphocyte subsets after stroke might be of clinical/therapeutic significance because animal data argue for a cerebroprotective effect of, for example, CD4+CD25+ regulatory T cells.

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