α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in Rats | Zendy

Kamil Ďuriš | Zendy; Anatol Manaenko | Zendy; Hidenori Suzuki | Zendy; William Rolland | Zendy; Paul R. Krafft | Zendy; John H. Zhang | Zendy

Open Access

α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates Early Brain Injury in a Perforation Model of Subarachnoid Hemorrhage in Rats

Author(s) -

Kamil Ďuriš,

Anatol Manaenko,

Hidenori Suzuki,

William Rolland,

Paul R. Krafft,

John H. Zhang

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.619965

Subject(s) - wortmannin , medicine , perforation , protein kinase b , agonist , subarachnoid hemorrhage , pharmacology , endocrinology , anesthesia , phosphorylation , receptor , microbiology and biotechnology , biology , materials science , metallurgy , punching

Early brain injury is an important pathological process after subarachnoid hemorrhage (SAH). The goal of this study was to evaluate whether the α7 nicotinic acetylcholine receptor (α7nAChR) agonist PNU-282987 attenuates early brain injury after SAH and whether α7nAChR stimulation is associated with down-regulation of caspase activity via phosphatidylinositol 3-kinase-Akt signaling.

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