Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome | Zendy

Kyra J. Becker | Zendy; Angela Kalil | Zendy; Pat Tanzi | Zendy; Dannielle Zierath | Zendy; Anna Savos | Zendy; James M Gee | Zendy; Jessica Hadwin | Zendy; Kelly Carter | Zendy; Dean Shibata | Zendy; Kevin C. Cain | Zendy

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Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome

Author(s) -

Kyra J. Becker,

Angela Kalil,

Pat Tanzi,

Dannielle Zierath,

Anna Savos,

James M Gee,

Jessica Hadwin,

Kelly Carter,

Dean Shibata,

Kevin C. Cain

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.619593

Subject(s) - medicine , stroke (engine) , myelin basic protein , modified rankin scale , immune system , immunology , antigen , central nervous system , brain ischemia , myelin , ischemia , ischemic stroke , mechanical engineering , engineering

Immune responses to brain antigens occur after stroke, and experimental studies show that the likelihood of developing a detrimental autoimmune response to these antigens is increased by systemic inflammation at the time of stroke. The aim of this study was to determine if patients who developed infection in the poststroke period would be similarly predisposed to develop autoimmune responses to central nervous system antigens.

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