Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats. | Zendy

Tomoya Kinouchi | Zendy; Keiko T Kitazato | Zendy; Kenji Shimada | Zendy; Kenji Yagi | Zendy; Yoshiteru Tada | Zendy; Nobuhisa Matsushita | Zendy; Manabu Sumiyoshi | Zendy; Junichiro Satomi | Zendy; Teruyoshi Kageji | Zendy; Shinji Nagahiro | Zendy

Open Access

Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats.

Author(s) -

Tomoya Kinouchi,

Keiko T Kitazato,

Kenji Shimada,

Kenji Yagi,

Yoshiteru Tada,

Nobuhisa Matsushita,

Manabu Sumiyoshi,

Junichiro Satomi,

Teruyoshi Kageji,

Shinji Nagahiro

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

ISSN - 1524-4628

DOI - 10.1161/strokeaha.111.618926

The role of the phosphorylated signal transducer and activator of transcription-3 (p-STAT3) after cerebral ischemia by the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (PGZ) remains controversial. Whether the increase in p-STAT3 by estrogen is mediated by the estrogen receptor α is also obscure. We examined the role of p-STAT3, PPARγ, and estrogen receptor α against ischemic brain damage after PGZ treatment.

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