Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke | Zendy

Xuefang Ren | Zendy; Kozaburo Akiyoshi | Zendy; Arthur A. Vandenbark | Zendy; Patricia D. Hurn | Zendy; Halina Offner | Zendy

Open Access

Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke

Author(s) -

Xuefang Ren,

Kozaburo Akiyoshi,

Arthur A. Vandenbark,

Patricia D. Hurn,

Halina Offner

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.613182

Subject(s) - medicine , microglia , central nervous system , inflammation , stroke (engine) , immune system , middle cerebral artery , immunology , ischemia , mechanical engineering , engineering

Evaluation of infarct volumes and infiltrating immune cell populations in mice after middle cerebral artery occlusion strongly implicates a mixture of both pathogenic and regulatory immune cell subsets that affect stroke outcome. Our goal was to evaluate the contribution of the well-described coinhibitory pathway, programmed death (PD)-1, to the development of middle cerebral artery occlusion.

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