Human Umbilical Vein Endothelial Cells Protect Against Hypoxic-Ischemic Damage in Neonatal Brain via Stromal Cell-derived Factor 1/C-X-C Chemokine Receptor Type 4 | Zendy

Chia-Ching Wu | Zendy; YiChi Chen | Zendy; Ying-Chao Chang | Zendy; LanWan Wang | Zendy; YungChieh Lin | Zendy; Yi-Lun Chiang | Zendy; Chien-Jung Ho | Zendy; Chao Huang | Zendy

Open Access

Human Umbilical Vein Endothelial Cells Protect Against Hypoxic-Ischemic Damage in Neonatal Brain via Stromal Cell-derived Factor 1/C-X-C Chemokine Receptor Type 4

Author(s) -

Chia-Ching Wu,

YiChi Chen,

Ying-Chao Chang,

LanWan Wang,

YungChieh Lin,

Yi-Lun Chiang,

Chien-Jung Ho,

Chao Huang

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000719

Subject(s) - medicine , neuroprotection , stromal cell , umbilical vein , human umbilical vein endothelial cell , endothelial stem cell , immunology , pathology , pharmacology , biology , in vitro , biochemistry

Agents that protect against neurovascular damage provide a powerful neuroprotective strategy. Human umbilical vein endothelial cells (HUVECs) may be used to treat neonates with hypoxic-ischemia (HI) because of its autologous capability. We hypothesized that peripherally injected HUVECs entered the brain after HI, protected against neurovascular damage, and provided protection via stromal cell-derived factor 1/C-X-C chemokine receptor type 4 pathway in neonatal brain.

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