Open AccessPreclinical Investigations for Thrombectomy Devices—Does it Translate to Humans?
Author(s) -
Matthew J. Gounis,
Ajay K. Wakhloo,
Ju-Yu Chueh
Publication year - 2013
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.111.000692
Subject(s) - medicine , embolus , stroke (engine) , food and drug administration , clinical trial , new england , acute stroke , surgery , medical emergency , mechanical engineering , engineering , politics , tissue plasminogen activator , law , political science
Currently, most preclinical models to validate thrombectomy technologies have not directly translated to the clinical arena. Herein, we review our strategy that combines in vitro and in vivo modeling to assess thrombectomy device safety and efficacy quantitatively
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