Simvastatin Attenuates Stroke-induced Splenic Atrophy and Lung Susceptibility to Spontaneous Bacterial Infection in Mice | Zendy

Rong Jin | Zendy; Xiaolei Zhu | Zendy; Lin Liu | Zendy; Anil Nanda | Zendy; D. Neil Granger | Zendy; Guohong Li | Zendy

Open Access

Simvastatin Attenuates Stroke-induced Splenic Atrophy and Lung Susceptibility to Spontaneous Bacterial Infection in Mice

Author(s) -

Rong Jin,

Xiaolei Zhu,

Lin Liu,

Anil Nanda,

D. Neil Granger,

Guohong Li

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000633

Subject(s) - medicine , simvastatin , stroke (engine) , lung infection , lung , atrophy , pathology , immunology , mechanical engineering , engineering

Statins are widely used in the primary and secondary prevention of ischemic stroke, but their effects on stroke-induced immunodepression and poststroke infections are elusive. We investigated the effects of simvastatin treatment on stroke-induced splenic atrophy and lung susceptibility to bacterial infection in acute experimental stroke in mice.

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