Open AccessMiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation
Author(s) -
Haiping Zhao,
Jun Wang,
Li Gao,
Rongliang Wang,
Xiangrong Liu,
Zhi Gao,
Zhen Tao,
Changmin Xu,
Juexian Song,
Xunming Ji,
Yumin Luo
Publication year - 2013
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.111.000504
Subject(s) - medicine , microglia , ischemia , western blot , pathology , apoptosis , middle cerebral artery , inflammation , biology , biochemistry , gene
We observed that microRNA-424 (miR-424) significantly decreased in an miRNA profile of circulating lymphocytes of patients with ischemic stroke. The present study focused on the potential and mechanism of miR-424 in protecting ischemic brain injury in mice.
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