Constraint-Induced Movement Therapy Overcomes the Intrinsic Axonal Growth–Inhibitory Signals in Stroke Rats | Zendy

Shanshan Zhao | Zendy; Mei Zhao | Zendy; Ting Xiao | Zendy; Jukka Jolkkonen | Zendy; Chuansheng Zhao | Zendy

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Constraint-Induced Movement Therapy Overcomes the Intrinsic Axonal Growth–Inhibitory Signals in Stroke Rats

Author(s) -

Shanshan Zhao,

Mei Zhao,

Ting Xiao,

Jukka Jolkkonen,

Chuansheng Zhao

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000361

Subject(s) - biotinylated dextran amine , medicine , synaptophysin , constraint induced movement therapy , rhoa , inhibitory postsynaptic potential , stroke (engine) , neuroplasticity , postsynaptic potential , neuroscience , anesthesia , cardiology , immunohistochemistry , receptor , surgery , central nervous system , signal transduction , psychology , biology , microbiology and biotechnology , mechanical engineering , upper limb , psychiatry , engineering

Constraint-induced movement therapy (CIMT) improves functional outcome in patients with stroke possibly through structural plasticity. We hypothesized that CIMT could enhance axonal growth by overcoming the intrinsic growth-inhibitory signals, leading eventually to improved behavioral performance in stroke rats.

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