Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke | Zendy

Cindy T. J. van Velthoven | Zendy; R. Ann Sheldon | Zendy; Annemieke Kavelaars | Zendy; Nikita Derugin | Zendy; Zinaida S. Vexler | Zendy; Hanneke L.D.M. Willemen | Zendy; Mirjam Maas | Zendy; Cobi J. Heijnen | Zendy; Donna M. Ferriero | Zendy

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Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke

Author(s) -

Cindy T. J. van Velthoven,

R. Ann Sheldon,

Annemieke Kavelaars,

Nikita Derugin,

Zinaida S. Vexler,

Hanneke L.D.M. Willemen,

Mirjam Maas,

Cobi J. Heijnen,

Donna M. Ferriero

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000326

Subject(s) - medicine , mesenchymal stem cell , neurotrophic factors , transplantation , brain derived neurotrophic factor , stroke (engine) , anesthesia , pathology , mechanical engineering , receptor , engineering

Brain injury caused by stroke is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. Mesenchymal stem cells (MSC) have been shown to improve outcome after neonatal hypoxic-ischemic brain injury mainly by secretion of growth factors stimulating repair processes. We investigated whether MSC treatment improves recovery after neonatal stroke and whether MSC overexpressing brain-derived neurotrophic factor (MSC-BDNF) further enhances recovery.

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