Effects of Minocycline Plus Tissue Plasminogen Activator Combination Therapy After Focal Embolic Stroke in Type 1 Diabetic Rats | Zendy

Xiang Fan | Zendy; Eng H. Lo | Zendy; Xiaoying Wang | Zendy

Open Access

Effects of Minocycline Plus Tissue Plasminogen Activator Combination Therapy After Focal Embolic Stroke in Type 1 Diabetic Rats

Author(s) -

Xiang Fan,

Eng H. Lo,

Xiaoying Wang

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000309

Subject(s) - medicine , minocycline , stroke (engine) , embolic stroke , plasminogen activator , tissue plasminogen activator , diabetes mellitus , cardiology , ischemic stroke , endocrinology , ischemia , antibiotics , engineering , mechanical engineering , microbiology and biotechnology , biology

Poststroke hyperglycemia is associated with resistance to tissue plasminogen activator (tPA) reperfusion, higher risk of intracerebral hemorrhage, and worse neurological outcomes. In this study, we asked whether minocycline combined with intravenous tPA may ameliorate inflammation and brain injury after focal embolic stroke in type 1 diabetic rats.

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