Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis | Zendy

Hugh S. Markus | Zendy; Kari-Matti Mäkelä | Zendy; Steve Bevan | Zendy; Emma Raitoharju | Zendy; Niku Oksala | Zendy; Joshua C. Bis | Zendy; Chris O’Donnell | Zendy; Atticus H. Hainsworth | Zendy; Terho Lehtimäki | Zendy

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Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis

Author(s) -

Hugh S. Markus,

Kari-Matti Mäkelä,

Steve Bevan,

Emma Raitoharju,

Niku Oksala,

Joshua C. Bis,

Chris O’Donnell,

Atticus H. Hainsworth,

Terho Lehtimäki

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000217

Subject(s) - medicine , pathology , stroke (engine) , asymptomatic , population , cardiology , mechanical engineering , environmental health , engineering

A novel association between a single nucleotide polymorphism on chromosome 7p21.1 and large-vessel ischemic stroke was recently identified. The most likely underlying gene is histone deacetylase 9 (HDAC9). The mechanism by which HDAC9 increases stroke risk is not clear; both vascular and neuronal mechanisms have been proposed.

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