Erythropoietin Increases Neurogenesis and Oligodendrogliosis of Subventricular Zone Precursor Cells After Neonatal Stroke | Zendy

Fernando F. Gonzalez | Zendy; Amara Larpthaveesarp | Zendy; Patrick S. McQuillen | Zendy; Nikita Derugin | Zendy; Michael F. Wendland | Zendy; Ruggero Spadafora | Zendy; Donna M. Ferriero | Zendy

Open Access

Erythropoietin Increases Neurogenesis and Oligodendrogliosis of Subventricular Zone Precursor Cells After Neonatal Stroke

Author(s) -

Fernando F. Gonzalez,

Amara Larpthaveesarp,

Patrick S. McQuillen,

Nikita Derugin,

Michael F. Wendland,

Ruggero Spadafora,

Donna M. Ferriero

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000104

Subject(s) - subventricular zone , neun , neurogenesis , medicine , erythropoietin , neural stem cell , progenitor cell , green fluorescent protein , stroke (engine) , pathology , stem cell , neuroscience , biology , microbiology and biotechnology , immunohistochemistry , mechanical engineering , biochemistry , engineering , gene

Stroke is a common cause of neonatal brain injury. The subventricular zone is a lifelong source of newly generated cells in rodents, and erythropoietin (EPO) treatment has shown benefit in different animal models of brain injury. The purpose of this study is to investigate the specific role of exogenous EPO on subventricular zone progenitor cell populations in response to neonatal stroke.

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