Heritability Estimates Identify a Substantial Genetic Contribution to Risk and Outcome of Intracerebral Hemorrhage | Zendy

William J. Devan | Zendy; Guido J. Falcone | Zendy; Christopher D. Anderson | Zendy; Jeremiasz Jagiełła | Zendy; Helena Schmidt | Zendy; Björn M. Hansen | Zendy; Jordi JiménezConde | Zendy; Eva GiraltSteinhauer | Zendy; Elisa CuadradoGodia | Zendy; Carolina SorianoTárraga | Zendy; Alison Ayres | Zendy; Kristin Schwab | Zendy; Sylvia Baedorf Kassis | Zendy; Valerie Valant | Zendy; Joanna Pera | Zendy; Andrzej Urbanik | Zendy; Anand Viswanathan | Zendy; Natalia S. Rost | Zendy; Joshua N. Goldstein | Zendy; Paul Freudenberger | Zendy; Eva-Maria Stögerer | Zendy; Bo Norrving | Zendy; David Tirschwell | Zendy; Magdy Selim | Zendy; Devin L. Brown | Zendy; Scott Silliman | Zendy; Bradford B. Worrall | Zendy; James F. Meschia | Zendy; Chelsea S. Kidwell | Zendy; Joan Montaner | Zendy; Israel FernándezCadenas | Zendy; Pilar Delgado | Zendy; Steven M. Greenberg | Zendy; Jaume Roquer | Zendy; Arne Lindgren | Zendy; Agnieszka Słowik | Zendy; Reinhold Schmidt | Zendy; Daniel Woo | Zendy; Jonathan Rosand | Zendy; Alessandro Biffi | Zendy

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Heritability Estimates Identify a Substantial Genetic Contribution to Risk and Outcome of Intracerebral Hemorrhage

Author(s) -

William J. Devan,

Guido J. Falcone,

Christopher D. Anderson,

Jeremiasz Jagiełła,

Helena Schmidt,

Björn M. Hansen,

Jordi JiménezConde,

Eva GiraltSteinhauer,

Elisa CuadradoGodia,

Carolina SorianoTárraga,

Alison Ayres,

Kristin Schwab,

Sylvia Baedorf Kassis,

Valerie Valant,

Joanna Pera,

Andrzej Urbanik,

Anand Viswanathan,

Natalia S. Rost,

Joshua N. Goldstein,

Paul Freudenberger,

Eva-Maria Stögerer,

Bo Norrving,

David Tirschwell,

Magdy Selim,

Devin L. Brown,

Scott Silliman,

Bradford B. Worrall,

James F. Meschia,

Chelsea S. Kidwell,

Joan Montaner,

Israel FernándezCadenas,

Pilar Delgado,

Steven M. Greenberg,

Jaume Roquer,

Arne Lindgren,

Agnieszka Słowik,

Reinhold Schmidt,

Daniel Woo,

Jonathan Rosand,

Alessandro Biffi

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.111.000089

Subject(s) - medicine , intracerebral hemorrhage , heritability , stroke (engine) , subarachnoid hemorrhage , genetics , mechanical engineering , engineering , biology

Previous studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome.

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