Mesenchymal Stem Cells Primed With Valproate and Lithium Robustly Migrate to Infarcted Regions and Facilitate Recovery in a Stroke Model | Zendy

LiKai Tsai | Zendy; Zhifei Wang | Zendy; Jeeva Munasinghe | Zendy; Yan Leng | Zendy; Peter Leeds | Zendy; DeMaw Chuang | Zendy

Open Access

Mesenchymal Stem Cells Primed With Valproate and Lithium Robustly Migrate to Infarcted Regions and Facilitate Recovery in a Stroke Model

Author(s) -

LiKai Tsai,

Zhifei Wang,

Jeeva Munasinghe,

Yan Leng,

Peter Leeds,

DeMaw Chuang

Publication year - 2011

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.110.612788

Subject(s) - medicine , cxc chemokine receptors , angiogenesis , mesenchymal stem cell , pharmacology , transplantation , homing (biology) , chemokine receptor , anesthesia , immunology , chemokine , receptor , pathology , biology , ecology

The migratory efficiency of mesenchymal stem cells (MSC) toward cerebral infarct after transplantation is limited. Valproate (VPA) and lithium enhance in vitro migration of MSC by upregulating CXC chemokine receptor 4 and matrix metalloproteinase-9, respectively. Ability of VPA and lithium to promote MSC homing and to improve functional recovery was assessed in a rat model of cerebral ischemia.

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